Intraocular pressure elevation during radioactive plaque brachytherapy for uveal melanoma.

children (aged 6-16 years). An increase in IOP of 15 mm Hg or more was measured 11 patients (41%)—4 of 5 children and 7 of 22 adults. An increase of 20 mm Hg or more was seen in 2 of 5 children and 3 of 22 adults. The peak IOP was 30 mm Hg or higher in 3 of 5 children and 4 of 22 adults. All IOP increases responded to difluprednate discontinuation or addition of glaucoma medications. No patient required glaucoma surgery. The mean AC cell grade prior to starting difluprednate treatment was 1.7 on a scale of 0 to 4. Seven eyes (15%) of 7 patients had an AC cell grade of 0 prior to switching to difluprednate treatment. At the peak IOP while receiving difluprednate, a mean reduction in AC cell grade of 1.3 was measured. Twenty-five eyes (54%) had an AC cell grade of 0 when treated with difluprednate.